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What are the pharmacological effects of Kava Extra

3 year ago
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1. Nervous system effects (1) Anti-anxiety effect: Kavalactone can improve the attention, memory and reaction of patients with anxiety disorders, and make the patients in a relaxed state, but its effect is slow. The Jena University in Germany conducted a controlled experiment on 101 outpatients suffering from anxiety disorders and obsessive-compulsive neurosis. The patients were given 100 mg/day of kava extract and placebo. After 8 weeks, patients in the kava group had significant effects. (2) Sedative and hypnotic effects: intravenous or oral administration of dihydrocapsaicin or dihydronarcophyll has sedative and hypnotic effects on mice, rats, rabbits and cats. High doses can cause ataxia and Normal reflexes disappear. It is currently thought that kavapyrones may act through the GABA receptor binding site. (3) Anesthetic effect of Chemicalbook Department: Kava extract can cause muscle paralysis, local anesthetic effect on experimental frogs, and paralysis of the wings of bats and sparrows. The mechanism of action is similar to lidocaine, acting by blocking potential-dependent sodium channels. 2. Antifungal effect Kavapyrone has no inhibitory effect on the growth of Gram-positive or negative bacteria, and some kavapyrones have significant inhibitory effect on many fungi, including some human pathogens.
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