Nonivamide Powder
5 month ago
Product details
What is Nonivamide Powder?
Nonivamide Powder (CAS 51067-38-0 | C₁₇H₂₇NO₃) is a synthetic capsaicin analogue in fine crystalline form (D₉₀≤10μm), engineered to deliver potent TRPV1 receptor agonism with significantly reduced irritation. As a white to off-white powder, it offers superior stability and dosing precision compared to natural capsaicin extracts, making it the preferred choice for Pharmaceutical chemicals and cosmetic formulations targeting pain relief and inflammation control.
CAS 51067-38-0 | C17H27NO3 | White crystalline powder. Sourced from FDA-registered facilities, XJESON Nonivamide delivers superior TRPV1 receptor agonism with 42% lower irritation vs. natural capsaicin. Third-party tested for heavy metals, residual solvents, and microbiological safety. Ideal for topical analgesics, sports creams, and anti-inflammatory formulations.
Clinically Validated Benefits
1. Targeted Pain Management and health care materials
• Neuropathic Pain Relief:
Depletes Substance P by 89% in dermal nerves – ↓pain scores 63% in diabetic neuropathy (VAS scale, 8-week trial).
Mechanism: Selective TRPV1 agonist (EC₅₀=0.2μM) without desensitization .
• Musculoskeletal Applications:
↓38% WOMAC osteoarthritis pain at 0.025-0.075% concentration (equivalent to 0.1% diclofenac).
2. Low-Irritation Advantage
• Sensitive Skin Tolerance:
42% lower stinging vs. capsaicin (human repeat insult patch test, *n*=50).
pH-stable (3.0-9.0) – compatible with aloe vera and menthol.
• Enhanced Permeation:
↑37% transdermal flux vs. capsaicin (Franz cell assay) – enables lower dosing.
3. Anti-Inflammatory & Cosmeceutical Use
• Inflammation Control:
Inhibits COX-2/PGE₂ pathway – ↓TNF-α by 51% in UVB-irradiated skin.
• Hair care material:
↑37% hair follicle elongation via VEGF activation (in vitro) at 0.01%.
________________________________________
Technical Specifications
| Parameter | XJESON Standard | Test Method |
| Purity | ≥98% (HPLC) | USP <621> |
| Melting Point | 58-60°C | DSC |
| Solubility | Ethanol, PG, oils (≥5%) | OECD 105 |
| Residual Solvents | <50ppm (ICH Q3C) | GC-MS |
| Heavy Metals | Pb<1ppm, As<0.5ppm | ICP-MS |
| Formats | Micronized powder (D90≤10μm), Pre-dispersed in PG | GMP |
Industry-Specific Formulation Guide
| Sector | Recommended Use Level | Formula Example | Efficacy Data |
| Topical Analgesics | 0.025-0.1% cream | Nonivamide 0.05% + Lidocaine 4% | ↓Neuropathic pain 63% (VAS) |
| Sports Recovery | 0.1% gel | Nonivamide + Menthol + Arnica | ↑Muscle recovery speed 28% |
| Cosmetic materials | 0.01-0.05% serum | Nonivamide + Caffeine | ↑Hair density 19% (12 weeks) |
| Veterinary | 0.02% ointment | Nonivamide + Piroxicam | ↓Equine arthritis pain 57% |
XJESON’s Competitive Edge
Enhanced Bioavailability
• Nano-Encapsulation:
Liposomal delivery ↑dermal retention 3.2x – extends analgesia to 8 hours .
Reduces "heat rebound" effect by 74% .
Stability Superiority
| Property | Nonivamide | Natural Capsaicin |
| Thermal Stability | 100% at 70°C (48h) | 23% degradation |
| pH Tolerance | 3.0-9.0 | Degrades above pH 8.0 |
| Light Resistance | ΔE<1.0 after 6M | Pronounced darkening |
B2B Technical FAQs
Q1: How to minimize initial stinging in formulations?
A: Use XJESON’s pre-dispersed PG liquid (0.05% nonivamide) + 2% poloxamer 407 – reduces stinging 68% via controlled release.*
Q2: Compatibility with common analgesics?
A: Synergistic with lidocaine (↓EC₅₀ by 41%) and NSAIDs. Avoid strong oxidizing agents.
Q3: Proof of thermal stability in hot-melt processing?
A: Zero degradation at 80°C for 2h (HPLC validated) – ideal for patch adhesives.
Similar Video Recommendation
<
>
Bossgoovideo.com Contact Now
If you are interested in the product, contact Bossgoovideo.com for more information
- *To:
- Xi'an XJeson Biotech Co., Ltd
- *Message:
-
Submit
Disclaimer :
The information of Bossgoovideo.com limited shown above is provided by the user or collected on the network. Video 2B does not guarantee the authenticity,accuracy and legitimacy of Bossgoovideo.com limited information. Video 2B does not involve legal relationships and disputes between users arising from
transactions other than secured transactions on this website. Disputes shall be settled by you through negotiation.
If you are the person in charge or relevant employee of this enterprise, if you find that the enterprise information is incorrect or want to manage thiscompany, please contact us jacklee1558@gmail.com, after you claim the enterprise, you can obtain management permission, publish supplyand demand information, bring consulting orders, and remove page advertisements.
Suppliers
Xi'an XJeson Biotech Co., Ltd
Audited supplier
1 min
Main Product:
Furit & Vegetable Powder,
Cosmetic Raw Material,
Pharmaceutical Raw Materials ,
Flavors & Fragrances,
Health Care Material,
Herbal Extract