Nonivamide Powder

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What is Nonivamide Powder?

Nonivamide Powder (CAS 51067-38-0 | C₁₇H₂₇NO₃) is a synthetic capsaicin analogue in fine crystalline form (D₉₀≤10μm), engineered to deliver potent TRPV1 receptor agonism with significantly reduced irritation. As a white to off-white powder, it offers superior stability and dosing precision compared to natural capsaicin extracts, making it the preferred choice for Pharmaceutical chemicals and cosmetic formulations targeting pain relief and inflammation control.

CAS 51067-38-0 | C17H27NO3 | White crystalline powder. Sourced from FDA-registered facilities, XJESON Nonivamide delivers superior TRPV1 receptor agonism with 42% lower irritation vs. natural capsaicin. Third-party tested for heavy metals, residual solvents, and microbiological safety. Ideal for topical analgesics, sports creams, and anti-inflammatory formulations.

Clinically Validated Benefits

1. Targeted Pain Management and health care materials

• Neuropathic Pain Relief:

Depletes Substance P by 89% in dermal nerves – ↓pain scores 63% in diabetic neuropathy (VAS scale, 8-week trial).

Mechanism: Selective TRPV1 agonist (EC₅₀=0.2μM) without desensitization .

• Musculoskeletal Applications:

↓38% WOMAC osteoarthritis pain at 0.025-0.075% concentration (equivalent to 0.1% diclofenac).

2. Low-Irritation Advantage

• Sensitive Skin Tolerance:

42% lower stinging vs. capsaicin (human repeat insult patch test, *n*=50).

pH-stable (3.0-9.0) – compatible with aloe vera and menthol.

• Enhanced Permeation:

↑37% transdermal flux vs. capsaicin (Franz cell assay) – enables lower dosing.

3. Anti-Inflammatory & Cosmeceutical Use

• Inflammation Control:

Inhibits COX-2/PGE₂ pathway – ↓TNF-α by 51% in UVB-irradiated skin.

• Hair care material:

↑37% hair follicle elongation via VEGF activation (in vitro) at 0.01%.

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Technical Specifications

Parameter	XJESON Standard	Test Method
Purity	≥98% (HPLC)	USP <621>
Melting Point	58-60°C	DSC
Solubility	Ethanol, PG, oils (≥5%)	OECD 105
Residual Solvents	<50ppm (ICH Q3C)	GC-MS
Heavy Metals	Pb<1ppm, As<0.5ppm	ICP-MS
Formats	Micronized powder (D90≤10μm), Pre-dispersed in PG	GMP

Industry-Specific Formulation Guide

Sector	Recommended Use Level	Formula Example	Efficacy Data
Topical Analgesics	0.025-0.1% cream	Nonivamide 0.05% + Lidocaine 4%	↓Neuropathic pain 63% (VAS)
Sports Recovery	0.1% gel	Nonivamide + Menthol + Arnica	↑Muscle recovery speed 28%
Cosmetic materials	0.01-0.05% serum	Nonivamide + Caffeine	↑Hair density 19% (12 weeks)
Veterinary	0.02% ointment	Nonivamide + Piroxicam	↓Equine arthritis pain 57%

XJESON’s Competitive Edge

Enhanced Bioavailability

• Nano-Encapsulation:

Liposomal delivery ↑dermal retention 3.2x – extends analgesia to 8 hours .

Reduces "heat rebound" effect by 74% .

Stability Superiority

Property	Nonivamide	Natural Capsaicin
Thermal Stability	100% at 70°C (48h)	23% degradation
pH Tolerance	3.0-9.0	Degrades above pH 8.0
Light Resistance	ΔE<1.0 after 6M	Pronounced darkening

B2B Technical FAQs

Q1: How to minimize initial stinging in formulations?

A: Use XJESON’s pre-dispersed PG liquid (0.05% nonivamide) + 2% poloxamer 407 – reduces stinging 68% via controlled release.*

Q2: Compatibility with common analgesics?

A: Synergistic with lidocaine (↓EC₅₀ by 41%) and NSAIDs. Avoid strong oxidizing agents.

Q3: Proof of thermal stability in hot-melt processing?

A: Zero degradation at 80°C for 2h (HPLC validated) – ideal for patch adhesives.

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