Azelaic Acid

Azelaic Acid Product Description

Azelaic acid, also known as rhododendron acid, is a natural compound extracted from rhododendron petals, as well as sources like pyrethrum and cocoa bean fat. It offers powerful antibacterial and anti-inflammatory properties, making it highly effective in treating acne, seborrheic dermatitis, superficial fungal infections, and pigmentation. Azelaic acid also helps to exfoliate dead skin cells, clear pores, and reduce blemishes.

Key Benefits and Functions of Azelaic Acid

1. Antibacterial Properties

   • Azelaic acid inhibits protein synthesis in bacteria, targeting both aerobic and anaerobic bacteria on the skin surface and within hair follicles.
   • At high concentrations (> 250 mmol/L), it effectively kills Staphylococcus epidermidis, Pseudomonas aeruginosa, Propionibacterium acnes, Candida albicans, and other microbes.
   • Even at lower concentrations (2.5 mmol/L), it inhibits bacterial growth. Azelaic acid’s antibacterial effect increases in low pH environments, allowing it to penetrate deeper into cells.

2. Sebum Regulation

   • Azelaic acid controls sebum production by competitively inhibiting 5-α reductase, an enzyme that converts androgens into dihydrotestosterone (DHT).
   • By reducing DHT levels, it minimizes excessive fatty acid secretion from sebaceous glands, addressing oily skin issues.
   • It also helps in preventing and treating male hormonal alopecia (hair loss caused by excess androgens), stimulating hair growth when used at concentrations between 0.01% and 1%.

3. Anti-Inflammatory and Antioxidant Action

   • Azelaic acid reduces oxidative stress by inhibiting the production of free radicals and reactive oxygen species (ROS).
   • It prevents the hydroxylation of aromatic compounds and blocks the peroxidation of arachidonic acid, thereby reducing inflammation and soothing irritated skin.

Applications

• Skincare: Azelaic acid is widely used in products for acne treatment, rosacea, pigmentation, and skin texture improvement.
• Haircare: It aids in managing androgenic alopecia by balancing hormone activity and encouraging hair growth.
• Medical Treatments: Azelaic acid is used clinically to manage seborrheic dermatitis and superficial fungal infections due to its antimicrobial properties.

With its multifunctional benefits, azelaic acid is recognized as a versatile and safe ingredient for both dermatological treatments and cosmetic formulations. Its ability to address a variety of skin conditions makes it a popular choice among dermatologists and consumers alike.Trust in our Pharmaceutical Chemicals, Chinese Herb Extracts, and APIs for high-quality formulations!