Dihydroberberine

Dihydroberberine (DHB) is a chemically modified herbal extract derived from berberine, engineered to enhance absorption and minimize side effects. At CNCSBIO, we define DHB as "a super-charged berberine for nutritional supplements, delivering better health outcomes"—highlighting its superior bioavailability. As a hydrogenated derivative of berberine, the addition of hydrogen atoms enables the body to absorb DHB far more efficiently than standard berberine, potentially reducing required dosages while lowering the risk of gastrointestinal discomfort.

The most notable benefit of DHB is its superior absorption: Clinical studies confirm that a 100mg dose of dihydroberberine achieves significantly higher plasma levels—5 times greater—than a 500mg dose of standard berberine. This makes DHB a more efficient, cost-effective alternative for nutritional supplement formulations, with reduced risk of digestive side effects commonly associated with berberine.

As a potent antimicrobial herbal extract, DHB is widely used in nutritional supplements and functional ingredients to address various bacterial and fungal infections, including diarrhea, dysentery, and gastrointestinal infections. Additionally, its role in weight management support—leveraging metabolic regulation properties—makes it a popular choice for wellness and weight loss supplement formulations.

Dihydroberberine is a naturally occurring isoquinoline alkaloid found in select medicinal plants, including Coptis chinensis Franch. (Ranunculaceae, commonly known as Chinese goldthread) and Phellodendron chinense Schneid. (Rutaceae, Chinese corktree). CNCSBIO’s bulk dihydroberberine powder is derived from high-quality plant sources, ensuring purity and consistency for industrial applications.

For optimal results in finished supplements, DHB is typically formulated as capsules or tablets, with a suggested serving size taken with or immediately after meals (breakfast, lunch, or dinner). Its high bioavailability allows for flexible dosing strategies, supporting diverse product development needs for nutritional supplement brands.