Amarogentin (Gentian Extract)

What does Amarogentin do?

Amarogentin, a prominent Chinese herb extract derived from the roots of traditional medicinal plants such as Swertia and Gentiana species, is a schizocyclic iridoid glycoside that has gained recognition for its diverse array of natural health-promoting properties. In the realm of Natural Food Healthy Products, Amarogentin serves as a powerful ingredient due to its rich content of Natural Extracts.

This bioactive compound exhibits multiple biological effects that contribute significantly to human health. It possesses potent antioxidant qualities, which neutralize free radicals and protect cells from oxidative stress. Moreover, Amarogentin demonstrates anti-tumor activities by fostering apoptosis – programmed cell death in cancer cells – and interfering with the cell cycle at the G2/M phase, effectively inhibiting tumor growth.

Its hepato protective attributes make it an attractive component in Health ingredient that support liver function, while its immunomodulatory effects help regulate the immune system, thereby maintaining a balanced response to pathogens and internal threats.

Furthermore, Amarogentin showcases anti-diabetic potential through the down-regulation of the PI3K/Akt/mTOR signaling pathway, a key molecular cascade involved in insulin resistance and glucose metabolism. Its beneficial impact on vascular health also comes into play as it activates AMPK (adenosine monophosphate-activated protein kinase), a master metabolic regulator that improves overall metabolic efficiency within blood vessels and other tissues.

In conclusion, Amarogentin, extracted from these valuable Chinese herbs, stands out as a promising natural food healthy product ingredient due to its array of plant-based therapeutic actions targeting various aspects of physiological well-being.

Effect:

1. Liver protection

Gentiolate glycosides prevent liver cancer by regulating the control point of G1/S cell cycle and inducing cell apoptosis. In a mouse model of CCL4-induced liver cancer, one group of mice was given gentiolate glycoside 15 days before cancer, The other group was given gentiate glucoside one week after the carcinogenesis. 30 weeks later, the mice given before the carcinogenesis had no significant changes in liver morphology and tissue structure, and no pathological changes such as weight loss and lymphocyte penetration, while the mice given after the carcinogenesis had small lesions on the liver surface, moderate dysplasia of liver structure, and lymphocyte penetration. Compared with the control group, the proliferative cells of the pre-cancerous mice were significantly reduced and the apoptotic number was increased, while the proliferative cells of the post-cancerous mice were increased and the apoptotic number was decreased. It can be seen that the preventive effect of gentiolate glycoside is more effective than the therapeutic effect. 0.2 mg/g is the most effective dose of gentiolate glycoside.

2. Anti-tumor effect

Cox is a rate-limiting enzyme that converts arachidonic acid into prostaglandins in cells. Cox-ii expression induced by mitosis, oncogenes, and tumor metastasis can promote tumor cell proliferation and angiogenesis. Apoptotic protease (Procaspase-3) exists as an inactive precursor in cells and is activated by the p11p17 subunit to induce apoptosis. In a mouse model of skin cancer induced by DMBA(dimethylbenzanthracene dimethylbenzanthracene), It was found that the target of gentiolate glycoside is Cox-II and apoptotic protease (Procaspase-3), which can induce apoptosis and inhibit tumor proliferation by down-regulating the expression of COX-II and activating the apoptotic protease.

3. Anti-kala-azar action

The amastigote of Leishmania donei is mainly parasitic in the macrophages of liver, spleen, bone marrow, lymph nodes and other organs, and often causes systemic symptoms, such as fever, hepatosplenomegaly, anemia, epistaxis and so on. Patients often have dark pigmentation of the skin and fever, which is also called kala-azar. Due to its strong pathogenicity, it often dies from complications without treatment, and the fatality rate can be as high as 90%. It has been found that gentiate side can inhibit topoisomerase I, prevent it from binding with DNA, inhibit parasite proliferation, and show anti-leishmania effect. Swapna Medda et al. injected leishmania into hamsters and divided them into four groups, giving free gentioside, its liposomes and its vesicles respectively. After 30 days, it was found that the incidence of parasites in the treatment group (free, liposomes and vesicles) was reduced by 34%, 69% and 90%, respectively. Mice given free gentiolate glycoside did not die in any of the five dose groups, and the optimal therapeutic dose was 2.5 mg/kg. In addition, it was found that the anti-leishmaniasis action of gentiolate glycoside was dose-dependent, and it had the same anti-protozoan effect as camptothecin.

Peroration

It has been proved that gentioside is beneficial to digestion, liver protection, anti-skin tumor, anti-kala-azar and other curative effects and biosafety, and has attracted attention in vitro and animal experiments. However, there is still a lot of research work on whether gentiate side has clinical application prospect and whether it can be developed into a new hepatoprotective drug or anti-tumor drug.