Imidazole

Imidazole CAS No.:288-32-4 is more prone to electrophilic aromatic substitution reactions than other 1,3-diazoles, and the reactions mainly occur on C-4 and C-5. The acylation reaction of imidazole generally occurs on N-3, but since the acyl group is an electron withdrawing group, the reaction can be controlled in the monoacylation stage, and the product is N-acylimidazole.The active hydrogen of imidazole can decompose Grignard reagent to generate N-magnesium salt of imidazole, which can be isomerized to obtain C-2-substituted imidazole. The latter can be treated with iodomethane to generate 1,2-dimethylimidazole.Imidazole Cas:288-32-4 can undergo addition with dienophiles, first forming 3-onium salt zwitterions, and then nucleophilically adding with another molecule of dienophile to generate C-2 cyclized products. For example, after reacting 1-methyl-2-ethylimidazole with two molecules of dimethyl butynedioate, 8 α - ethyl-1-methyl-1,8 α - dihydroimidazo [1,2-a] pyridine-5,6,7,8-tetracarboxylic acid tetramethyl ester is obtained.